Everything about Gdp-fucose Protein O-fucosyltransferase 2 totally explained
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an
enzyme responsible for adding
fucose sugars in
O linkage to
serine or
threonine residues in
Thrombospondin repeats. The protein is an inverting
glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in
O linkage to the protein producing fucose-α-
O-serine/threonine.
Almost all glycosyltransferases reside in the
Golgi apparatus. However, POFUT2 as well as the related
enzyme POFUT1 have recently been shown to reside in the
endoplasmic reticulum.
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